Serping1 Gene Summary [Rat]
Predicted to enable complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway. Located in extracellular space. Used to study glioblastoma. Biomarker of acute myocardial infarction. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serping1 |
| Official Name | serpin family G member 1 [Source:RGD Symbol;Acc:735225] |
| Ensembl ID | ENSRNOG00000007457 |
| Bio databases IDs | |
| Aliases | serpin family G member 1 |
| Synonyms | C1 esterase inhibitor precursor, C1-IA, C1INH, C1INH., C1 Inhibitor, C1-inhibitor precursor, C1 INH precursor, C1NH, complement C1-esterase inhibitor precursor, Complement C1 Inhibitor, complement C1-inhibitor precursor, HAE1, HAE2, PPC1I, serine (or cysteine) peptidase inhibitor, clade G, member 1, serpin family G member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Serping1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- protein binding
- Serpin (serine protease inhibitor)
Pathways
Biological processes and signaling networks where the Serping1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- epithelial cancer
- hereditary disorder
- hereditary angioedema
- liver cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- hereditary angioedema type I
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- cellular infiltration by
- expression in
- binding
- quantity
- activation
- adhesion
- degradation in
- breakdown
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- endoplasmic reticulum lumen
- alpha granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Serping1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation, classical pathway
- innate immune response
- negative regulation of complement activation, lectin pathway
- blood circulation
- negative regulation of endopeptidase activity
- blood coagulation
- fibrinolysis
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding