Dnm2 Gene Summary [Rat]
Enables several functions, including D2 dopamine receptor binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including cytoskeleton organization; endocytosis; and positive regulation of cellular component organization. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and ruffle membrane. Part of protein-containing complex. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (dynamin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnm2 |
| Official Name | dynamin 2 [Source:RGD Symbol;Acc:2513] |
| Ensembl ID | ENSRNOG00000007649 |
| Bio databases IDs | |
| Aliases | dynamin 2 |
| Synonyms | b2b2159Clo, CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYIIAAB, DYN2, DYNAMIN 2, DYNII, LCCS5, Udnm |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology Region 1
- Protein of unknown function (DUF3729)
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- G-protein-coupled receptor binding
- enzyme
- proline rich domain
- Dynamin family
- Mucin-like
- phosphatidylinositol-4,5-bisphosphate binding
- PH domain
- tail domain
- Src phosphorylation site
- P-loop containing Nucleoside Triphosphate Hydrolases
- Dynamin GTPase effector domain
- proline glycine arginine motif
- protein kinase binding
- enzyme binding
- WW domain binding
- GTPase
- protein binding
- Pleckstrin homology-like domain
- SH3-domain binding
- GTP binding
- phosphoinositide 3-kinase binding
- binding protein
- GTPase domain
- Dynamin central region
Pathways
Biological processes and signaling networks where the Dnm2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital heart disease
- hyperalgesia
- lymphopenia
- Charcot-Marie-Tooth disease, dominant intermediate type B
- hyperglycemia
- hypotrophy
- hereditary disorder
- dominant intermediate Charcot-Marie-Tooth disease type B with neutropenia
- ischemic stroke
- centronuclear myopathy
role in cell
- proliferation
- internalization by
- endocytosis
- endocytosis in
- morphology
- formation
- extension
- expression in
- apoptosis
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- cell junction
- endocytic vesicle membrane
- organelle
- Cytoplasm
- cell periphery
- perinuclear region
- outer membranes
- cellular membrane
- cell cortex
- Nucleus
- endosomes
- vesicles
- centrosome
- Golgi Apparatus
- centriole
- microtubules
- cytosol
- membrane ruffles
- uropod
- postsynaptic membrane
- Golgi membrane
- trans Golgi network
- perinuclear space
- acrosome
- proacrosomic vesicles
- growth cone
- neurites
- photoreceptor inner segments
- recycling endosomes
- late endosomes
- endocytotic vesicle
- membrane rafts
- clathrin-coated pits
- cell membrane leading edge
- meiotic spindles
- dendrites
- postsynaptic density
- clathrin-coated vesicles
- lamellipodia
- phagocytic cups
- macropinosomes
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- centrosome cycle
- transferrin transport
- signal transduction
- neuron projection morphogenesis
- regulation of transcription, DNA-dependent
- post-Golgi vesicle-mediated transport
- stress fiber assembly
- endocytosis
- receptor-mediated endocytosis
- protein polymerization
- regulation of axon extension
- G2/M transition of mitotic cell cycle
- synaptic vesicle transport
- positive regulation of transcription, DNA-dependent
- autophagy
- synaptic vesicle budding from presynaptic membrane
- positive regulation of apoptotic process
- phagocytosis
- receptor internalization
- antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- Golgi apparatus
- Golgi membrane
- synapse
- phagocytic cup
- neuron projection
- podosome
- microtubule
- growth cone
- extracellular vesicular exosome
- endosome
- focal adhesion
- postsynaptic membrane
- coated pit
- cytosol
- endocytic vesicle membrane
- plasma membrane
- centrosome
- uropod
- cytoplasm
- centriole
- phagocytic vesicle membrane
- recycling endosome
- midbody
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- GTP binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- GTPase activity
- SH3 domain binding
- microtubule binding
- enzyme binding