Il27 Gene Summary [Rat]
Predicted to enable interleukin-27 receptor binding activity. Involved in response to Gram-positive bacterium. Located in cell surface. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il27 |
| Official Name | interleukin 27 [Source:RGD Symbol;Acc:1561420] |
| Ensembl ID | ENSRNOG00000019170 |
| Bio databases IDs | |
| Aliases | interleukin 27 |
| Synonyms | IL-27-A, IL-27p28, IL30, interleukin 27, p28, RGD1561420 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il27 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-27 receptor binding
- poly(Glu) domain
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the Il27 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- COVID-19
- neoplasia
- glioma
- glioma formation
- bacteremia
- allergic airway inflammation
- stenosis
- visceral leishmaniasis
- airway hyperresponsiveness
role in cell
- inhibition in
- expression in
- phosphorylation in
- production in
- cellular infiltration by
- binding
- apoptosis
- survival
- proliferation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cytosol
- endoplasmic reticulum lumen
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il27 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- inflammatory response
- signal transduction
- innate immune response
- positive regulation of interferon-gamma production
- positive regulation of defense response to virus by host
- regulation of T-helper 1 cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- cytosol
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- interleukin-27 receptor binding
- cytokine activity
- receptor binding