Gas2 Gene Summary [Rat]
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | Gas2 |
| Official Name | growth arrest-specific 2 [Source:RGD Symbol;Acc:1563167] |
| Ensembl ID | ENSRNOG00000016717 |
| Bio databases IDs | |
| Aliases | growth arrest-specific 2 |
| Synonyms | DFNB125, growth arrest-specific 2, RGD1563167 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gas2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- calponin homology (CH) domain superfamily
- protein binding
- Growth-Arrest-Specific Protein 2 Domain
Pathways
Biological processes and signaling networks where the Gas2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic kidney disease
- leukemia
- hearing loss
- autosomal recessive deafness
role in cell
- expression in
- apoptosis
- migration
- growth
- cellular infiltration by
- detachment
- organization
- cell rounding
- shrinkage
- disruption
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- actin filaments
- cytosol
- microfilaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gas2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- actin crosslink formation
- initiation of primordial ovarian follicle growth
- antral ovarian follicle growth
- regulation of Notch signaling pathway
- ovulation
- apoptotic process
- basement membrane organization
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- membrane
- stress fiber
- cytosol
- actin filament
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- cytoskeletal adaptor activity
- microtubule binding