Pla2g2d Gene Summary [Rat]
Predicted to enable several functions, including calcium-dependent phospholipase A2 activity; heparan sulfate proteoglycan binding activity; and heparin binding activity. Predicted to be involved in glycerophospholipid metabolic process; negative regulation of T cell proliferation; and regulation of acute inflammatory response to antigenic stimulus. Predicted to act upstream of or within CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation and negative regulation of T cell activation. Predicted to be located in extracellular region. Orthologous to human PLA2G2D (phospholipase A2 group IID). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pla2g2d |
| Official Name | phospholipase A2, group IID [Source:RGD Symbol;Acc:1309862] |
| Ensembl ID | ENSRNOG00000016826 |
| Bio databases IDs | |
| Aliases | phospholipase A2, group IID |
| Synonyms | phospholipase A2 group IID, phospholipase A2, group IID, PLA2IID, sPLA2-IID, sPLA2S, SPLASH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pla2g2d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- calcium-dependent phospholipase A2
- enzyme
- protein binding
- heparin binding
- phospholipase A2
- PLA2_like
Pathways
Biological processes and signaling networks where the Pla2g2d gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- cardiac fibrosis
- chronic obstructive pulmonary disease
regulates
- phospholipid
- phosphatidylcholine
- arachidonic acid
- phosphatidylethanolamine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pla2g2d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylglycerol metabolic process
- regulation of acute inflammatory response to antigenic stimulus
- inflammatory response
- phosphatidylcholine metabolic process
- arachidonic acid secretion
- negative regulation of T cell proliferation
- lipid catabolic process
- phosphatidylethanolamine metabolic process
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- phospholipid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- calcium-dependent phospholipase A2 activity
- calcium ion binding
- heparan sulfate proteoglycan binding
- heparin binding
- phospholipid binding