Dsc3 Gene Summary [Rat]
Predicted to enable calcium ion binding activity and gamma-catenin binding activity. Predicted to be involved in cell-cell adhesion and protein stabilization. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in several cellular components, including cell junction; extracellular region; and plasma membrane. Predicted to be active in desmosome. Orthologous to human DSC3 (desmocollin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dsc3 |
| Official Name | desmocollin 3 [Source:RGD Symbol;Acc:1311782] |
| Ensembl ID | ENSRNOG00000017159 |
| Bio databases IDs | |
| Aliases | desmocollin 3 |
| Synonyms | 5430426I24RIK, CDHF3, desmocollin 3, Desmocollin 4, DSC, DSC1, DSC2, DSC4, HT-CP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dsc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Cadherin, Y-type LIR-motif
- Cadherin prodomain like
- gamma-catenin binding
- intracellular domain
- Cadherin repeat-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- hypotrichosis and recurrent skin vesicles
- ETV6-RUNX1 positive B-lineage acute lymphoblastic leukemia
- Netherton syndrome
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- severe preeclampsia
- spindle cell carcinoma
role in cell
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cornified envelope
- cell junction
- Cytoplasm
- Extracellular Space
- cellular membrane
- intercellular junctions
- desmosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dsc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- cell-cell junction
- cytoplasm
- membrane
- cell junction
- desmosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- gamma-catenin binding
- calcium ion binding