Afap1l2 Gene Summary [Rat]
Predicted to enable SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Predicted to be involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human AFAP1L2 (actin filament associated protein 1 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Afap1l2 |
| Official Name | actin filament associated protein 1-like 2 [Source:RGD Symbol;Acc:1310668] |
| Ensembl ID | ENSRNOG00000017164 |
| Bio databases IDs | |
| Aliases | actin filament associated protein 1-like 2 |
| Synonyms | actin filament associated protein 1-like 2, CTB-1144G6.4, KIAA1914, mKIAA1914, PI3KAP/XB130, RGD1310668, XB130 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Afap1l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cortexillin I, coiled coil
- SH2-domain binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
- Src-homology 2 binding domain
- SH3-domain binding
- protein tyrosine kinase activator
- Sh3 domain binding motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- coronary artery disease
- myocardial infarction
role in cell
- proliferation
- apoptosis
- phosphorylation in
- survival
- activation in
- growth
- G1 phase
- mitosis
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Afap1l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of interleukin-8 production
- inflammatory response
- positive regulation of transcription, DNA-dependent
- positive regulation of epidermal growth factor receptor signaling pathway
- regulation of interleukin-6 production
- regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein tyrosine kinase activator activity
- SH3 domain binding
- SH2 domain binding