Ndufs8 Gene Summary [Rat]
Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex I. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 2. Orthologous to human NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufs8 |
| Official Name | NADH:ubiquinone oxidoreductase core subunit S8 [Source:RGD Symbol;Acc:1309436] |
| Ensembl ID | ENSRNOG00000017446 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase core subunit S8 |
| Synonyms | CI-23k, CI-23kD, MC1DN2, NADH dehydrogenase (ubiquinone) Fe-S protein 8, NADH:ubiquinone oxidoreductase core subunit S8, TYKY |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndufs8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 4Fe-4S dicluster domain
- 4Fe-4S double cluster binding domain
- NADH-quinone oxidoreductase, chain I
- NADH2 dehydrogenase
- 4Fe-4S binding domain
- enzyme
- protein binding
- NADH2 dehydrogenase (ubiquinone)
Pathways
Biological processes and signaling networks where the Ndufs8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nuclear type 2 mitochondrial complex I deficiency
- bipolar disorder
- adult acute myeloid leukemia
- mitochondrial disorder
- Leigh syndrome
- chronic obstructive pulmonary disease
regulates
- Mitochondrial ETC 1
role in cell
- survival
- autophagy in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndufs8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- NADH dehydrogenase activity
- protein binding
- metal ion binding
- NADH dehydrogenase (ubiquinone) activity
- 4 iron, 4 sulfur cluster binding