Pde6a Gene Summary [Rat]
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling and retina development in camera-type eye. Predicted to act upstream of or within photoreceptor cell maintenance. Predicted to be active in photoreceptor outer segment membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa 43. Orthologous to human PDE6A (phosphodiesterase 6A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde6a |
| Official Name | phosphodiesterase 6A [Source:RGD Symbol;Acc:1306835] |
| Ensembl ID | ENSRNOG00000017816 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 6A |
| Synonyms | CGPR-A, nmf282, PDEA, phosphodiesterase 6A, phosphodiesterase 6A, cGMP-specific, rod, alpha, phosphodiesterase 6A, cGMP-specific, rod, α, Rod cgmp phosphodiesterase alpha subunit, Rod cgmp phosphodiesterase α subunit, RP43 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'5'-cyclic nucleotide phosphodiesterase
- 3',5'-cyclic-GMP phosphodiesterase
- GAF domain
- enzyme
- Domain present in phytochromes and cGMP-specific phosphodiesterases
Pathways
Biological processes and signaling networks where the Pde6a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- schizophrenia
- mild COVID-19
- hypertension
- retinitis pigmentosa
- retinitis pigmentosa type 43
- pulmonary hypertension
- PDE6A-related retinopathy
- pulmonary emphysema
- heart failure
role in cell
- cell death
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- rod outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina development in camera-type eye
- visual perception
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- photoreceptor outer segment membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity