Pde6b Gene Summary [Rat]
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in retinal cell apoptotic process. Predicted to be located in photoreceptor outer segment. Predicted to be active in photoreceptor outer segment membrane. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 2 and retinitis pigmentosa 40. Orthologous to human PDE6B (phosphodiesterase 6B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde6b |
| Official Name | phosphodiesterase 6B [Source:RGD Symbol;Acc:1311039] |
| Ensembl ID | ENSRNOG00000000065 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 6B |
| Synonyms | beta-subunit of rod cGMP-PDE, beta-subunit of rod cGMP-phosphodiesterase, cGMP Phosphodiesterase Beta Subunit, cGMP Phosphodiesterase β Subunit, CSNB3, CSNBAD2, cyclic guanosine monophosphate-phosphodiesterase beta-subunit, cyclic guanosine monophosphate-phosphodiesterase β-subunit, GMP-PDEbeta, PDEB, phosphodiesterase 6B, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, phosphodiesterase 6B, cGMP, rod receptor, β polypeptide, rd, rd-1, rd10, rod cGMP-phosphodiesterase beta-subunit, rod cGMP-phosphodiesterase β-subunit, RP40, β-PDE, β-subunit of rod cGMP-PDE, β-subunit of rod cGMP-phosphodiesterase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- catalytic domain
- GAF domain
- enzyme
- HDc
- 3',5'-cyclic-nucleotide phosphodiesterase
- Domain present in phytochromes and cGMP-specific phosphodiesterases
Pathways
Biological processes and signaling networks where the Pde6b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinal dystrophy
- retinal degeneration
- retinitis pigmentosa
- retinitis pigmentosa type 40
- autosomal recessive retinitis pigmentosa
- autosomal dominant congenital stationary night blindness type 2
- rodless retina disease
- spinocerebellar ataxia type 7
- Huntington disease
- tyrosinase-positive oculocutaneous albinism
role in cell
- quantity
- apoptosis
- survival
- cell death
- activation
- function
- loss
- degeneration
- morphology
- preservation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- photoreceptor outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phototransduction, visible light
- retina development in camera-type eye
- entrainment of circadian clock by photoperiod
- visual perception
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- photoreceptor outer segment membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity