Dctpp1 Gene Summary [Rat]
Predicted to enable several functions, including dCTP diphosphatase activity; magnesium ion binding activity; and pyrimidine deoxyribonucleotide binding activity. Predicted to be involved in DNA protection and dCTP catabolic process. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in cytosol. Orthologous to human DCTPP1 (dCTP pyrophosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dctpp1 |
| Official Name | dCTP pyrophosphatase 1 [Source:RGD Symbol;Acc:620933] |
| Ensembl ID | ENSRNOG00000017850 |
| Bio databases IDs | |
| Aliases | dCTP pyrophosphatase 1 |
| Synonyms | 2410015N17Rik, CDA03, dCTP pyrophosphatase 1, RS21-C6, XTP3TPA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dctpp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- binding protein
- pyrophosphatase
- dCTP diphosphatase
- nucleoside-triphosphate diphosphatase
- MazG-like family
- enzyme
- protein binding
- pyrimidine nucleotide binding
- magnesium ion binding
- NTP-PPase
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
- B cell cancer
- gastric adenocarcinoma
- gastric epithelial cancer
regulates
- nucleoside triphosphate
- dCTP
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dctpp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dTTP catabolic process
- DNA protection
- nucleoside triphosphate catabolic process
- dCTP catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- identical protein binding
- protein binding
- dCTP diphosphatase activity
- nucleoside-triphosphate diphosphatase activity
- pyrimidine deoxyribonucleotide binding