DCTPP1 Gene Summary [Human]
The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | DCTPP1 |
| Official Name | dCTP pyrophosphatase 1 [Source:HGNC Symbol;Acc:HGNC:28777] |
| Ensembl ID | ENSG00000179958 |
| Bio databases IDs | |
| Aliases | dCTP pyrophosphatase 1, XTP3-transactivated protein A |
| Synonyms | 2410015N17Rik, CDA03, dCTP pyrophosphatase 1, RS21-C6, XTP3TPA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCTPP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- binding protein
- pyrophosphatase
- dCTP diphosphatase
- nucleoside-triphosphate diphosphatase
- MazG-like family
- enzyme
- protein binding
- pyrimidine nucleotide binding
- magnesium ion binding
- NTP-PPase
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- MYC mutation positive B-cell lymphoma
- lymphomagenesis
- B cell cancer
- gastric adenocarcinoma
- gastric epithelial cancer
regulates
- nucleoside triphosphate
- dCTP
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCTPP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dTTP catabolic process
- DNA protection
- nucleoside triphosphate catabolic process
- dCTP catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- identical protein binding
- protein binding
- dCTP diphosphatase activity
- nucleoside-triphosphate diphosphatase activity
- pyrimidine deoxyribonucleotide binding