F12 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including positive regulation of plasminogen activation; protein maturation; and regulation of blood coagulation. Located in extracellular space. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in angioedema (multiple); cerebrovascular disease (multiple); factor XII deficiency; and myocardial infarction. Orthologous to human F12 (coagulation factor XII). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | F12 |
| Official Name | coagulation factor XII [Source:RGD Symbol;Acc:1359175] |
| Ensembl ID | ENSRNOG00000015139 |
| Bio databases IDs | |
| Aliases | coagulation factor XII |
| Synonyms | coagulation factor XII, coagulation factor XII (Hageman factor), factor XII, FACTOR XIIA, FXII, HAE3, HAEX, HAF, Hageman factor, α-factor XIIa |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat F12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KR
- Trypsin-like serine protease
- serine endopeptidase
- trypsin
- Tryp_SPc
- catalytic domain
- peptidase
- FN1
- protein binding
- coagulation factor XIIa
- FN2
- EGF_CA
Pathways
Biological processes and signaling networks where the F12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- cardiovascular disorder
- thromboembolism
- bleeding
- acute respiratory distress syndrome
- neuroinflammation
- factor XII deficiency
- coronary artery disease
- tinnitus
- liver cancer
role in cell
- proliferation
- phosphorylation in
- growth
- migration
- binding
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat F12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of blood coagulation
- positive regulation of fibrinolysis
- blood coagulation, intrinsic pathway
- blood coagulation
- fibrinolysis
- plasma kallikrein-kinin cascade
- Factor XII activation
- zymogen activation
- innate immune response
- protein autoprocessing
- protein processing
- positive regulation of plasminogen activation
- response to misfolded protein
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- rough endoplasmic reticulum
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- serine-type endopeptidase activity
- misfolded protein binding