Tctn1 Gene Summary [Rat]
Predicted to be involved in cilium assembly and protein localization to ciliary transition zone. Predicted to act upstream of or within in utero embryonic development; nervous system development; and regulation of smoothened signaling pathway. Predicted to be located in ciliary transition zone; extracellular space; and membrane. Predicted to be part of MKS complex. Human ortholog(s) of this gene implicated in Joubert syndrome 13. Orthologous to human TCTN1 (tectonic family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tctn1 |
| Official Name | tectonic family member 1 [Source:RGD Symbol;Acc:1566266] |
| Ensembl ID | ENSRNOG00000028523 |
| Bio databases IDs | |
| Aliases | tectonic family member 1 |
| Synonyms | 4930565B19Rik, FLJ21127, G730031O11Rik, JBTS13, RGD1566266, TECT1, Tectonic, tectonic family member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tctn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tectonic domain DUF1619
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- joubert syndrome type 13
- Joubert syndrome related disorder
- metastasis
- organismal death
- developmental disorder
- Joubert syndrome
role in cell
- expression in
- phosphorylation in
- migration
- formation
- differentiation
- invasion by
- morphology
- formation in
- assembly
- polymerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ciliary transition zone
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tctn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dorsal/ventral neural tube patterning
- neural tube formation
- cilium morphogenesis
- telencephalon development
- central nervous system interneuron axonogenesis
- in utero embryonic development
- somatic motor neuron differentiation
- regulation of smoothened signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoskeleton
- membrane
- cytosol
- TCTN-B9D complex