Rad17 Gene Summary [Rat]
Predicted to enable chromatin binding activity and chromatin-protein adaptor activity. Predicted to contribute to DNA clamp loader activity. Predicted to be involved in several processes, including mitotic DNA integrity checkpoint signaling; negative regulation of DNA replication; and protein localization to site of double-strand break. Predicted to act upstream of or within DNA damage response. Predicted to be located in chromosome, telomeric region; nucleolus; and nucleoplasm. Predicted to be part of Rad17 RFC-like complex. Predicted to be active in site of double-strand break. Orthologous to human RAD17 (RAD17 checkpoint clamp loader component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad17 |
| Official Name | RAD17 checkpoint clamp loader component [Source:RGD Symbol;Acc:1309515] |
| Ensembl ID | ENSRNOG00000018353 |
| Bio databases IDs | |
| Aliases | RAD17 checkpoint clamp loader component |
| Synonyms | CCYC, HRAD17, MmRad24, R24L, RAD17 checkpoint clamp loader component, RAD17SP, RAD24 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rad17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA ATPase domain
- helical lid domain of clamp loader-like AAA+ proteins
- protein binding activity, bridging
- Rad17 P-loop domain
- checkpoint protein rad24
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Rad17 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- breast cancer
- multiple sclerosis
role in cell
- cell cycle progression
- cell death
- quantity
- formation
- checkpoint control
- accumulation
- formation in
- survival
- G2/M phase transition
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
- nucleoli
- PML nuclear bodies
- telomeres
- replication fork
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rad17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA damage checkpoint
- DNA replication checkpoint
- intra-S DNA damage checkpoint
- negative regulation of DNA replication
- chromatin organization
- response to DNA damage stimulus
- regulation of phosphorylation
- mitotic cell cycle DNA replication checkpoint
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- site of double-strand break
- nucleolus
- Rad17 RFC-like complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA clamp loader activity
- protein binding
- chromatin binding