Taldo1 Gene Summary [Rat]
Enables monosaccharide binding activity and transaldolase activity. Involved in fructose 6-phosphate metabolic process and pentose-phosphate shunt, non-oxidative branch. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder. Orthologous to human TALDO1 (transaldolase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taldo1 |
| Official Name | transaldolase 1 [Source:RGD Symbol;Acc:620674] |
| Ensembl ID | ENSRNOG00000018367 |
| Bio databases IDs | |
| Aliases | transaldolase 1 |
| Synonyms | TAL, TALDOR, TAL-H, Transaldolase, transaldolase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Taldo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transaldolase
- monosaccharide binding
- TIM-like beta/alpha barrel domains
- enzyme
- protein binding
- carbohydrate binding
- identical protein binding
- Transaldolase/Fructose-6-phosphate aldolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- deficiency of transaldolase
- severe acute respiratory syndrome
- proteinuria
- chronic kidney disease
- systemic juvenile idiopathic arthritis
- asthenozoospermia
- diabetic peripheral neuropathy
- gastric adenocarcinoma
- gastric epithelial cancer
role in cell
- function
- accumulation in
- cell proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Taldo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pentose-phosphate shunt, non-oxidative branch
- carbohydrate metabolic process
- fructose 6-phosphate metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- intracellular
Molecular Function
What the gene product does at the molecular level
- sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity
- protein binding
- monosaccharide binding