Klk8 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including keratinocyte proliferation; memory; and neuron projection morphogenesis. Predicted to act upstream of or within synapse organization. Predicted to be located in cytoplasm. Predicted to be part of serine protease inhibitor complex. Predicted to be active in extracellular space and secretory granule. Orthologous to human KLK8 (kallikrein related peptidase 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klk8 |
| Official Name | kallikrein related-peptidase 8 [Source:RGD Symbol;Acc:1305998] |
| Ensembl ID | ENSRNOG00000018580 |
| Bio databases IDs | |
| Aliases | kallikrein related-peptidase 8 |
| Synonyms | BSP1, HNP, Kallikrein 8, kallikrein related-peptidase 8, Klnh, neuropsin, NP, NRPN, Ovasin, PRSS19, TADG14 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klk8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- peptidase
- Trypsin-like peptidase domain
- protein binding
Pathways
Biological processes and signaling networks where the Klk8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- androgenic alopecia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- organismal death
- psoriasis
- pruritus
- ovarian cancer
- seizures
- non-small cell lung carcinoma
role in cell
- molecular cleavage in
- proliferation
- formation
- signaling in
- organization
- abnormal morphology
- polymerization in
- excitatory postsynaptic potential
- polymerization
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klk8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte proliferation
- regulation of synapse organization
- synapse organization
- proteolysis
- response to wounding
- neuron projection morphogenesis
- memory
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- secretory granule
- serine protease inhibitor complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity