Il17ra Gene Summary [Rat]
Predicted to enable interleukin-17 receptor activity and signaling receptor binding activity. Involved in cellular response to cytokine stimulus. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 51. Orthologous to human IL17RA (interleukin 17 receptor A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il17ra |
| Official Name | interleukin 17 receptor A [Source:RGD Symbol;Acc:1306559] |
| Ensembl ID | ENSRNOG00000011153 |
| Bio databases IDs | |
| Aliases | interleukin 17 receptor A |
| Synonyms | CANDF5, CD217, CDw217, hIL-17R, IL17FR, IL17R, IL17 receptor, IMD51, interleukin 17 receptor A, LOC150166, VDw217 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il17ra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- C-BAD domain
- TILL domain
- Interleukin 17 receptor D
- Interleukin-17 receptor, fibronectin-III-like domain 1
- interleukin-17 receptor
- SEFIR domain
- protein binding
- receptor binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il17ra gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Glucocorticoid Receptor Signaling
- IL-17 Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- IL-17A Signaling in Gastric Cells
- Role of IL-17A in Arthritis
- Role of IL-17A in Psoriasis
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- airway hyperresponsiveness
- rheumatoid arthritis
- psoriasis
- plaque psoriasis
- neoplasia
- psoriatic arthritis
- asthma
- infection
- glucose metabolism disorder
- familial candidiasis type 5
role in cell
- quantity
- phosphorylation in
- expression in
- binding in
- infiltration by
- production in
- growth
- number
- migration
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- basolateral cell surfaces
- growth cone
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il17ra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of chemokine (C-X-C motif) ligand 1 production
- protein catabolic process
- positive regulation of inflammatory response
- cell surface receptor signaling pathway
- response to virus
- positive regulation of cytokine production involved in inflammatory response
- inflammatory response
- positive regulation of interleukin-23 production
- positive regulation of interleukin-13 production
- innate immune response
- granulocyte chemotaxis
- positive regulation of interleukin-6 production
- defense response to fungus
- T-helper 17 type immune response
- positive regulation of interleukin-5 production
- fibroblast activation
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding
- interleukin-17 receptor activity