Rnf40 Gene Summary [Rat]
Enables syntaxin-1 binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-protein transferase activity. Involved in positive regulation of protein metabolic process; response to peptide hormone; and ubiquitin-dependent protein catabolic process. Part of protein-containing complex. Biomarker of nephrogenic diabetes insipidus. Orthologous to human RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf40 |
| Official Name | ring finger protein 40 [Source:RGD Symbol;Acc:628638] |
| Ensembl ID | ENSRNOG00000018840 |
| Bio databases IDs | |
| Aliases | ring finger protein 40 |
| Synonyms | BRE1-B, mKIAA0661, RBP95, ring finger protein 40, STARING |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rnf40 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- chromosome segregation protein SMC, primarily archaeal type
- enzyme binding
- enzyme
- protein binding
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- mRNA 3' UTR binding
- syntaxin-1 binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- BRE1 E3 ubiquitin ligase
- protein homodimerization
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital heart disease
regulated by
- lipopolysaccharide
- KDM5B
- TAFAZZIN
- geldanamycin
role in cell
- expression in
- activation in
- proliferation
- formation in
- formation
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- Nucleus
- nucleoplasm
- synaptosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rnf40 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin organization
- positive regulation of transcription from RNA polymerase II promoter
- regulation of mitotic cell cycle
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- membrane
- HULC complex
- neuron projection
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein homodimerization activity
- ubiquitin protein ligase binding
- protein binding
- metal ion binding
- mRNA 3'-UTR binding