Entr1 Gene Summary [Rat]
Predicted to be involved in several processes, including endocytic recycling; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Predicted to be located in endosome. Predicted to be part of retromer complex. Predicted to be active in endosome; microtubule organizing center; and midbody. Orthologous to human ENTR1 (endosome associated trafficking regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Entr1 |
| Official Name | endosome associated trafficking regulator 1 [Source:RGD Symbol;Acc:1305930] |
| Ensembl ID | ENSRNOG00000018876 |
| Bio databases IDs | |
| Aliases | endosome associated trafficking regulator 1 |
| Synonyms | C330016H24RIK, C630038K21Rik, endosome associated trafficking regulator 1, NY-CO-3, SDCCAG3, SDDAG3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Entr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- protein binding
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Takayasu arteritis
- inflammatory bowel disease
- insulin resistance
regulated by
role in cell
- expression in
- degradation in
- assembly
- ubiquitination in
- size
- cytokinesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
- endosomes
- centrosome
- midbody
- recycling endosomes
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Entr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- protein transport
- cell projection organization
- regulation of cytokinesis
- positive regulation of flagellum assembly
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- centrosome
- early endosome
- endosome
- cilium basal body
- retromer complex
- recycling endosome
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding