Plat Gene Summary [Rat]
Predicted to enable phosphoprotein binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to gonadotropin stimulus; and plasminogen activation. Located in extracellular space. Is active in several cellular components, including glutamatergic synapse; neuronal dense core vesicle; and perisynaptic space. Used to study disseminated intravascular coagulation and status epilepticus. Biomarker of brain edema; middle cerebral artery infarction; sciatic neuropathy; transient cerebral ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; hemophilia (multiple); osteonecrosis; and type 2 diabetes mellitus. Orthologous to human PLAT (plasminogen activator, tissue type). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plat |
| Official Name | plasminogen activator, tissue type [Source:RGD Symbol;Acc:3342] |
| Ensembl ID | ENSRNOG00000019018 |
| Bio databases IDs | |
| Aliases | plasminogen activator, tissue type |
| Synonyms | alteplase, alteplase, recombinant, D8Ertd2e, LOC100910418, PATISS, plasminogen activator, tissue, plasminogen activator, tissue type, recombinant tissue plasminogen activator, TAPI-1, tisokinase, tissue activator D 44, tissue plasminogen activator, tissue-type plasminogen activator, T-PA, T-plasminogen activator |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KR
- Trypsin-like serine protease
- Tryp_SPc
- catalytic domain
- peptidase
- Domain of unknown function (DUF1986)
- phosphoprotein binding
- signal peptide
- FN1
- protein binding
- receptor binding
- EGF-like domain
- EGF_CA
- T-plasminogen activator
- trypsin
- serine endopeptidase
- N-linked glycosylation site
- active site
Pathways
Biological processes and signaling networks where the Plat gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- stroke
- epithelial cancer
- systemic lupus erythematosus
- cardiovascular disorder
- pancreatic epithelial cancer
- angina pectoris
- infection
- acute ST-elevation myocardial infarction
- Alzheimer disease
role in cell
- cell death
- expression in
- phosphorylation in
- apoptosis
- cellular infiltration by
- survival
- proliferation
- quantity
- migration
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- chromaffin vesicle fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- apical compartment
- perinuclear region
- postsynaptic region
- Plasma Membrane
- granules
- synapse
- Weibel-Palade bodies
- secretory granules
- extracellular matrix
- chromaffin vesicles
- plasma
- mossy fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- negative regulation of fibrinolysis
- platelet-derived growth factor receptor signaling pathway
- negative regulation of proteolysis
- blood coagulation
- fibrinolysis
- prevention of polyspermy
- smooth muscle cell migration
- response to hypoxia
- negative regulation of plasminogen activation
- plasminogen activation
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- apical part of cell
- cytoplasm
- secretory granule
- serine protease inhibitor complex
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- phosphoprotein binding
- receptor binding