Ptpa Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; protein homodimerization activity; and protein phosphatase 2A binding activity. Predicted to contribute to phosphoprotein phosphatase activity. Predicted to be involved in mitotic spindle organization and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be part of ATPase complex; calcium channel complex; and protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpa |
| Official Name | protein phosphatase 2 phosphatase activator [Source:RGD Symbol;Acc:1308354] |
| Ensembl ID | ENSRNOG00000018457 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2 phosphatase activator |
| Synonyms | 2610042B21Rik, PARK25, PP2A, PP2A B, PP2A B', PPP2R4, PR53, protein phosphatase 2 phosphatase activator, protein phosphatase 2 protein activator |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptpa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein tyrosine phosphatase activator
- protein phosphatase
- protein phosphatase binding
- ATP binding
- phosphatase
- protein phosphatase regulator
- protein homodimerization
- protein binding
- receptor binding
- PTPA
- phosphatase binding
Pathways
Biological processes and signaling networks where the Ptpa gene in rat plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of Tissue Factor in Cancer
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- hypersomnia
- autosomal recessive early-onset Parkinson disease type 25 with impaired intellectual development
- atopic dermatitis
- neoplastic cell transformation
role in cell
- expression in
- apoptosis
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptpa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of phosphoprotein phosphatase activity
- positive regulation of phosphoprotein phosphatase activity
- mitotic spindle organization
- positive regulation of apoptotic process
- positive regulation of protein dephosphorylation
- negative regulation of protein dephosphorylation
- regulation of phosphoprotein phosphatase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- calcium channel complex
- cytoplasm
- protein phosphatase type 2A complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- phosphoprotein phosphatase activity
- protein tyrosine phosphatase activator activity
- peptidyl-prolyl cis-trans isomerase activity
- protein homodimerization activity
- protein binding
- metal ion binding
- receptor binding
- protein phosphatase 2A binding
- protein phosphatase regulator activity