Bmp15 Gene Summary [Rat]
Predicted to enable cytokine activity. Involved in positive regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in ovarian dysgenesis 2 and primary ovarian insufficiency. Orthologous to human BMP15 (bone morphogenetic protein 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmp15 |
| Official Name | bone morphogenetic protein 15 [Source:RGD Symbol;Acc:70990] |
| Ensembl ID | ENSRNOG00000002984 |
| Bio databases IDs | |
| Aliases | bone morphogenetic protein 15 |
| Synonyms | bone morphogenetic protein 15, GDF-9B, ODG2, POF4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bmp15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TGF_beta_SF
- Transforming growth factor beta like domain
- protein binding
- pro domain
- cleavage site
- growth factor
Pathways
Biological processes and signaling networks where the Bmp15 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- BMP signaling pathway
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- Iron homeostasis signaling pathway
- Molecular Mechanisms of Cancer
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- premature ovarian failure
- amenorrhea
- ovarian dysgenesis
- Parkinson disease
- premature ovarian failure type 4
- familial premature ovarian failure
- germ cell neoplasia
role in cell
- expression in
- proliferation
- growth
- differentiation
- phosphorylation in
- apoptosis
- expansion
- number
- mitosis
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bmp15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female gamete generation
- signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- cytokine activity