E2f3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of vascular associated smooth muscle cell apoptotic process; and protein import into nucleus. Predicted to act upstream of or within positive regulation of DNA-templated transcription and positive regulation of cell population proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and prostate cancer. Orthologous to human E2F3 (E2F transcription factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | E2f3 |
| Official Name | E2F transcription factor 3 [Source:RGD Symbol;Acc:1561600] |
| Ensembl ID | ENSRNOG00000029273 |
| Bio databases IDs | |
| Aliases | E2F transcription factor 3 |
| Synonyms | E2F transcription factor 3, LOC100361421, LOC691420, RGD1561600 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat E2f3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- dimerization domain
- DNA binding domain
- nucleic acid binding
- nuclear localization sequence
- transcription activation domain
- cyclin recognition motif
- protein binding
- Dimerization domain of E2F transcription factors
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- DP1 binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- cyclin A-binding domain
- double-stranded DNA binding
- E2F/DP family winged-helix DNA-binding domain
- transcription factor activity
- marked box
Pathways
Biological processes and signaling networks where the E2f3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Bladder Cancer Signaling
- Breast Cancer Regulation by Stathmin1
- Cell Cycle Regulation by BTG Family Proteins
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Estrogen-mediated S-phase Entry
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- epithelial neoplasia
- weight gain
- epithelial cancer
- cancer
- acute myeloid leukemia
- prostate cancer
- ovarian cancer
- hypoplasia
role in cell
- expression in
- apoptosis
- cell death
- survival
- colony formation
- activation in
- proliferation
- migration
- motility
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat E2f3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into nucleus
- positive regulation of cell proliferation
- G1/S transition of mitotic cell cycle
- negative regulation of fat cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- core promoter proximal region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity