Itga7 Gene Summary [Rat]
Enables integrin binding activity and laminin binding activity. Involved in cell adhesion; integrin-mediated signaling pathway; and skeletal muscle tissue development. Located in cell surface. Part of integrin complex. Used to study cardiomyopathy. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; and muscular disease. Orthologous to human ITGA7 (integrin subunit alpha 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itga7 |
| Official Name | integrin subunit alpha 7 [Source:RGD Symbol;Acc:71022] |
| Ensembl ID | ENSRNOG00000007905 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha 7 |
| Synonyms | [a]7, alpha7, integrin alpha 7, integrin subunit alpha 7, integrin subunit α 7, Integrin α 7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itga7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Integrin alpha (beta-propellor repeats)
- Integrin alpha
- binding protein
- cytoplasmic domain
- laminin binding
- cell adhesion molecule binding
- integrin binding
- protein binding
- cytosolic tail domain
- FG-GAP repeat
- FG-GAP-like repeat
Pathways
Biological processes and signaling networks where the Itga7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Caveolar-mediated Endocytosis Signaling
- Cdc42 Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HGF Signaling
- Integrin Signaling
- Molecular Mechanisms of Cancer
- Osteoarthritis Pathway
- PAK Signaling
- Paxillin Signaling
- PI3K/AKT Signaling
- PTEN Signaling
- Rac Signaling
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- single suture craniosynostosis
- congenital muscular dystrophy due to integrin alpha-7 deficiency
- endometriosis
- growth failure
- septic shock
- spondylarthritis
- kyphoscoliosis
- androgenic alopecia
- kyphosis
role in cell
- binding
- apoptosis
- proliferation
- function
- threonine phosphorylation in
- growth
- size
- survival
- differentiation
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- cellular membrane
- focal adhesions
- neuromuscular junctions
- sarcolemma
- cell-matrix adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itga7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- regulation of cell shape
- cell-matrix adhesion
- integrin-mediated signaling pathway
- cell adhesion mediated by integrin
- endodermal cell differentiation
- leukocyte migration
- heterotypic cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- integrin complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- integrin binding