Pde4c Gene Summary [Rat]
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cilium. Orthologous to human PDE4C (phosphodiesterase 4C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde4c |
| Official Name | phosphodiesterase 4C [Source:RGD Symbol;Acc:727918] |
| Ensembl ID | ENSRNOG00000019518 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 4C |
| Synonyms | AC008397.2, DPDE1, dunce, E130301F19, E130301F19Rik, Pde1/ivc, PDE21, phosphodiesterase 4C, phosphodiesterase 4C, cAMP specific |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pde4c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- cAMP-specific phosphodiesterase
- enzyme
- protein binding
- HDc
- Phosphodiesterase 4 upstream conserved regions (UCR)
- 3',5'-cyclic-nucleotide phosphodiesterase
Pathways
Biological processes and signaling networks where the Pde4c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- DISC1
- roflumilast
- L-826,141
- theophylline
- caffeine
- arofylline
- dyphylline
- tolbutamide
- cilomilast
- ketotifen
disease
- hypertension
- diabetes mellitus
- asthma
- HIV infection
- Parkinson disease
- chronic obstructive pulmonary disease
- obesity
- coronary disease
- infection
- pain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- cytosol
- primary cilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pde4c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cAMP catabolic process
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- perinuclear region of cytoplasm
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity