AABR07068316.1 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in response to glucose. Predicted to be located in extracellular matrix and sarcolemma. Predicted to be part of collagen trimer. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); chronic kidney disease; dystonia 27; muscular dystrophy (multiple); and primary open angle glaucoma. Orthologous to human COL6A3 (collagen type VI alpha 3 chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | AABR07068316.1 |
| Official Name | collagen type VI alpha 3 chain [Source:NCBI gene;Acc:367313] |
| Ensembl ID | ENSRNOG00000019648 |
| Bio databases IDs | |
| Aliases | collagen type VI alpha 3 chain |
| Synonyms | alpha3 (VI) COLLAGEN, BTHLM1, BTHLM1C, Collagen type VI alpha 3, collagen, type VI, alpha 3, collagen type VI alpha 3 chain, Collagen type VI α 3, collagen, type VI, α 3, collagen type VI α 3 chain, DYT27, UCMD1, UCMD1C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aabr07068316.1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular matrix structural constituent conferring tensile strength
- NC1 domain
- Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
- von Willebrand factor (vWF) type A domain
- globular domain
- C5 domain
- von Willebrand factor type A domain
- n-terminal subdomain
- triple helical domain
- noncollagenous domain
- FN3
- vWFA
- Collagen triple helix repeat (20 copies)
- c-terminal subdomain
- Histone H1-like nucleoprotein HC2
Pathways
Biological processes and signaling networks where the Aabr07068316.1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- breast carcinoma
- lung squamous cell carcinoma
- renal clear cell adenocarcinoma
- thyroid carcinoma
- hypertension
- urothelial bladder carcinoma
- cutaneous melanoma
- bladder cancer
- head and neck squamous cell carcinoma
role in cell
- expression in
- growth
- apoptosis
- formation
- quantity
- proliferation
- contact growth inhibition
- communication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell-associated matrix
- myofilaments
- lipid droplets
- endoplasmic reticulum lumen
- nuclear scaffolds
- sarcolemma
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aabr07068316.1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- response to glucose stimulus
- protein kinase B signaling cascade
- response to UV
- cell adhesion
- neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- sarcolemma
- extracellular matrix
- extracellular region
- collagen type VI
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- extracellular matrix structural constituent conferring tensile strength