Artn Gene Summary [Rat]
Predicted to enable growth factor activity. Involved in peripheral nervous system development. Predicted to be active in extracellular space. Used to study peripheral nervous system disease. Biomarker of peripheral nervous system disease. Orthologous to human ARTN (artemin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Artn |
| Official Name | artemin [Source:RGD Symbol;Acc:621427] |
| Ensembl ID | ENSRNOG00000019842 |
| Bio databases IDs | |
| Aliases | artemin |
| Synonyms | ART, ARTEMIN, ENOVIN, EVN, NBN, neublastin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Artn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TGF_beta_SF
- glial cell line-derived neurotrophic factor receptor binding
- Transforming growth factor beta like domain
- protein binding
- receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the Artn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- heat hyperalgesia
- cold allodynia
- cold pain
role in cell
- growth
- proliferation
- expression in
- migration
- cell viability
- activation in
- phosphorylation in
- response
- survival
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Artn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Peyer's patch morphogenesis
- glial cell-derived neurotrophic factor receptor signaling pathway
- neuroblast proliferation
- signal transduction
- peripheral nervous system development
- axon guidance
- lymphocyte migration into lymphoid organs
- induction of positive chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- receptor tyrosine kinase binding
- receptor binding
- glial cell line-derived neurotrophic factor receptor binding