Cox6a2 Gene Summary [Rat]
Predicted to enable enzyme regulator activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 18. Orthologous to human COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox6a2 |
| Official Name | cytochrome c oxidase subunit 6A2 [Source:RGD Symbol;Acc:2385] |
| Ensembl ID | ENSRNOG00000019851 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 6A2 |
| Synonyms | COX6AH, COXVIAH, COXVIa-M, Cytochrome c oxidase, polypeptide VIB, cytochrome c oxidase subunit 6A2, MC4DN18, VIaH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cox6a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- Cyt_c_Oxidase_VIa
- enzyme
Pathways
Biological processes and signaling networks where the Cox6a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- impaired glucose tolerance
- nuclear type 18 mitochondrial complex IV deficiency
- squamous-cell carcinoma
- squamous cell cancer
- hyperactive behavior
- dermatomyositis
- papilloma
- papillomatosis
- obesity
role in cell
- expression in
- maturation
- quantity
- disruption in
- disruption
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cox6a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- generation of precursor metabolites and energy
- mitochondrial electron transport, cytochrome c to oxygen
Cellular Component
Where in the cell the gene product is active
- mitochondrial respiratory chain complex IV
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity
- enzyme regulator activity