Slc16a1 Gene Summary [Rat]
Enables identical protein binding activity and lactate:proton symporter activity. Involved in plasma membrane lactate transport and pyruvate transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to human SLC16A1 (solute carrier family 16 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc16a1 |
| Official Name | solute carrier family 16 member 1 [Source:RGD Symbol;Acc:3690] |
| Ensembl ID | ENSRNOG00000019996 |
| Bio databases IDs | |
| Aliases | solute carrier family 16 member 1 |
| Synonyms | HHF7, MCT, MCT1, MCT1D, RATMCT1, RNMCT1, solute carrier family 16 member 1, solute carrier family 16 (monocarboxylic acid transporters), member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc16a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic acid transporter
- Major Facilitator Superfamily
- Multidrug resistance protein
- protein binding
- monocarboxylic acid transporter
- monocarboxylate transporter 1
- identical protein binding
- succinate transporter
- lactate transporter
- lactate:hydrogen porter
- mevalonate transporter
- cytosolic tail domain
- solute:hydrogen symporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- neoplasia
- familial hyperinsulinemic hypoglycemia type 7
- organismal death
- Rett syndrome
- autosomal dominant monocarboxylate transporter 1 deficiency
- autosomal recessive monocarboxylate transporter 1 deficiency
- refractive error
- Warburg effect
- ovarian cancer
role in cell
- growth
- survival
- expression in
- proliferation
- activation in
- binding in
- cell death
- production in
- degradation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell junction
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- centrosome
- Mitochondria
- granules
- apical membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- mitochondrial membrane
- myelin sheath
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc16a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- pyruvate catabolic process
- centrosome cycle
- regulation of insulin secretion
- behavioral response to nutrient
- lipid metabolic process
- glucose homeostasis
- monocarboxylic acid transport
- mevalonate transport
- succinate transmembrane transport
- plasma membrane lactate transport
- cellular response to organic cyclic compound
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- centrosome
- lateral plasma membrane
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- cell junction
- synapse
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- organic cyclic compound binding
- lactate:hydrogen symporter activity
- succinate transmembrane transporter activity
- mevalonate transmembrane transporter activity
- lactate transmembrane transporter activity
- carboxylic acid transmembrane transporter activity
- monocarboxylic acid transmembrane transporter activity