Pnkp

Predicted to enable ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; polynucleotide 3'-phosphatase activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including double-strand break repair via nonhomologous end joining; positive regulation of double-strand break repair via nonhomologous end joining; and protein K63-linked ubiquitination. Predicted to act upstream of or within positive regulation of telomere maintenance. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in nucleus and site of double-strand break. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B2; ataxia-oculomotor apraxia type 4; and microcephaly, seizures, and developmental delay. Orthologous to human PNKP (polynucleotide kinase 3'-phosphatase). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pnkp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Pnkp gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Pnkp gene, providing context for its role in the cell.