Neil2 Gene Summary [Rat]
Predicted to enable microtubule binding activity. Predicted to be involved in base-excision repair. Predicted to be located in cytoplasm; mitotic spindle; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human NEIL2 (nei like DNA glycosylase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neil2 |
| Official Name | nei-like DNA glycosylase 2 [Source:RGD Symbol;Acc:1312033] |
| Ensembl ID | ENSRNOG00000010696 |
| Bio databases IDs | |
| Aliases | nei-like DNA glycosylase 2 |
| Synonyms | Gm1212, NEH2, NEI2, nei like 2 (E. coli), nei-like DNA glycosylase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Neil2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- DNA N-glycosylase
- enzyme
- protein binding
- Fpg/Nei N-terminal protein domain
- Formamidopyrimidine-DNA glycosylase H2TH domain
Pathways
Biological processes and signaling networks where the Neil2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- chromosomal instability
- alcoholism
- rotator cuff injury
- cholecystitis
- ocular sarcoidosis
- infection by HIV
role in cell
- expression in
- recruitment
- quantity
- loss
- number
- damage in
- loss in
- replication in
- breakage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- Cytoplasm
- Mitochondria
- nucleoplasm
- perinuclear space
- mitotic spindle
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Neil2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- base-excision repair
- depyrimidination
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- DNA-(apurinic or apyrimidinic site) lyase activity
- DNA N-glycosylase activity
- damaged DNA binding
- microtubule binding