Pafah1b3 Gene Summary [Rat]
Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity. Contributes to platelet-activating factor acetyltransferase activity. Predicted to be involved in lipid catabolic process. Predicted to act upstream of or within spermatogenesis. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex. Orthologous to human PAFAH1B3 (platelet activating factor acetylhydrolase 1b catalytic subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pafah1b3 |
| Official Name | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 [Source:RGD Symbol;Acc:620333] |
| Ensembl ID | ENSRNOG00000020481 |
| Bio databases IDs | |
| Aliases | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 |
| Synonyms | alpha 1 PAF-AH subunit, mus[g], PAF-AH alpha 1, PAFAHG, Paf-ah isoform 1 α 1 subunit, PAF-AH α 1, platelet activating factor acetylhydrolase 1b catalytic subunit 3, platelet-activating factor acetylhydrolase 1b, catalytic subunit 3, platelet-activating factor acetylhydrolase, isoform 1b, subunit 3, α 1 PAF-AH subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pafah1b3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SGNH_hydrolase
- GDSL-like Lipase/Acylhydrolase family
- 1-alkyl-2-acetylglycerophosphocholine esterase
- binding protein
- SGNH domain (fused to AT3 domains)
- protein homodimerization
- enzyme
- protein binding
- identical protein binding
- platelet-activating factor acetyltransferase
- protein heterodimerization
- GDSL-like Lipase/Acylhydrolase
Pathways
Biological processes and signaling networks where the Pafah1b3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- azoospermia
- early missed abortion
- pervasive developmental disorder
regulates
- lipid
- 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid
- platelet activating factor-C16
- PAFAH1B1
- aspirin
role in cell
- apoptosis
- spermatogenesis
- number
- abnormal morphology
- hydrolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pafah1b3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- lipid catabolic process
- lipid metabolic process
- nervous system development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- 1-alkyl-2-acetylglycerophosphocholine esterase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- platelet-activating factor acetyltransferase activity
- 1-alkyl-2-acetylglycerophosphocholine esterase activity