Tuft1 Gene Summary [Rat]
Predicted to be a structural constituent of skin epidermis. Predicted to be located in cytoplasm. Predicted to be part of RNA polymerase II, core complex. Predicted to be active in I band. Orthologous to human TUFT1 (tuftelin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tuft1 |
| Official Name | tuftelin 1 [Source:RGD Symbol;Acc:1310373] |
| Ensembl ID | ENSRNOG00000020923 |
| Bio databases IDs | |
| Aliases | tuftelin 1 |
| Synonyms | LOC681982, tuftelin 1, WHSF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tuft1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of epidermis
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- idiopathic pulmonary fibrosis
- lung adenocarcinoma formation
- lung adenocarcinoma
- myocardial infarction
- woolly hair-skin fragility syndrome
- bleomycin-induced pulmonary fibrosis
- seborrheic keratosis
role in cell
- expression in
- proliferation
- phosphorylation in
- invasion by
- migration
- sphere formation
- contractility
- morphology
- disruption in
- disruption
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tuft1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone mineralization
- odontogenesis
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- extracellular region
- intracellular
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding
- structural constituent of tooth enamel