Sema6c Gene Summary [Rat]
Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in axon guidance. Predicted to be located in cell surface and cytoplasm. Predicted to be active in plasma membrane. Orthologous to human SEMA6C (semaphorin 6C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema6c |
| Official Name | semaphorin 6C [Source:RGD Symbol;Acc:3659] |
| Ensembl ID | ENSRNOG00000021101 |
| Bio databases IDs | |
| Aliases | semaphorin 6C |
| Synonyms | mKIAA1869, m-SemaY, m-SemaY2, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C, semaphorin 6C, Semaphorin Y, SEMAY |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sema6c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- extracellular domain
- Plexin repeat
- semaphorin receptor binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema6c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sema6c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- neural crest cell migration
- axon guidance
- semaphorin-plexin signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- semaphorin receptor binding