SEMA6C Gene Summary [Human]

This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. [provided by RefSeq, May 2010]

Details

Type
Protein Coding
Official Symbol
SEMA6C
Official Name
semaphorin 6C [Source:HGNC Symbol;Acc:HGNC:10740]
Ensembl ID
ENSG00000143434
Bio databases IDs NCBI: 10500 Ensembl: ENSG00000143434
Aliases semaphorin 6C, m-Sema Y2
Synonyms mKIAA1869, m-SemaY, m-SemaY2, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C, semaphorin 6C, Semaphorin Y, SEMAY
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEMA6C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • semaphorin domain
  • extracellular domain
  • Plexin repeat
  • semaphorin receptor binding
  • Sema domain
  • The Sema domain, a protein interacting module, of semaphorins and plexins

Pathways

Biological processes and signaling networks where the SEMA6C gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • atopic dermatitis
regulated by
regulates
role in cell
  • expression in
  • extension
  • phosphorylation in
  • growth
  • senescence
  • autophagy in
  • guidance
  • collapse

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Cytoplasm
  • cell surface
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SEMA6C gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative chemotaxis
  • neural crest cell migration
  • axon guidance
  • semaphorin-plexin signaling pathway
  • positive regulation of cell migration

Cellular Component

Where in the cell the gene product is active
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • chemorepellent activity
  • semaphorin receptor binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.