Sema6c Gene Summary [Mouse]
Enables semaphorin receptor binding activity. Predicted to be involved in several processes, including negative regulation of axon extension; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be located in cell surface and cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and spinal cord. Orthologous to human SEMA6C (semaphorin 6C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Sema6c |
| Official Name | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C [Source:MGI Symbol;Acc:MGI:1338032] |
| Ensembl ID | ENSMUSG00000038777 |
| Bio databases IDs | |
| Aliases | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C |
| Synonyms | mKIAA1869, m-SemaY, m-SemaY2, sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C, semaphorin 6C, Semaphorin Y, SEMAY |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema6c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- extracellular domain
- Plexin repeat
- semaphorin receptor binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema6c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema6c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- neural crest cell migration
- axon guidance
- semaphorin-plexin signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- semaphorin receptor binding