Tnfrsf25 Gene Summary [Rat]
Predicted to be involved in apoptotic process and signal transduction. Predicted to be active in plasma membrane. Orthologous to human TNFRSF25 (TNF receptor superfamily member 25). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf25 |
| Official Name | TNF receptor superfamily member 25 [Source:RGD Symbol;Acc:1598206] |
| Ensembl ID | ENSRNOG00000021814 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 25 |
| Synonyms | APO-3, DDR3, DR3, GEF720, LARD, PLEKHG5, TNF receptor superfamily member 25, TNFRSF12, TR3, TRAMP, tumor necrosis factor receptor superfamily, member 25, tumour necrosis factor receptor superfamily, member 25, Wsl, WSL-1, WSL-LR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnfrsf25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- extracellular domain
- tumor necrosis factor receptor
- intracellular domain
- TNFR/NGFR cysteine-rich region
- Tumor necrosis factor receptor superfamily (TNFRSF)
- Death Domain Superfamily of protein-protein interaction domains
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tnfrsf25 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atherosclerosis
- dextran sodium sulfate-induced colitis
- primary sclerosing cholangitis
- hypersensitivity pneumonitis
- ovalbumin-induced asthma
- systemic autoimmune syndrome
- asthma
role in cell
- activation in
- expression in
- apoptosis
- proliferation
- production in
- migration
- growth
- quantity
- cell death
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- membrane surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnfrsf25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tumor necrosis factor-mediated signaling pathway
- signal transduction
- apoptotic process
- apoptotic signaling pathway
- regulation of apoptotic process
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- tumor necrosis factor-activated receptor activity
- signaling receptor activity