Tnfsf13 Gene Summary [Rat]
Predicted to enable receptor ligand activity. Predicted to be involved in positive regulation of B cell proliferation and positive regulation of isotype switching to IgA isotypes. Predicted to act upstream of or within immunoglobulin mediated immune response; positive regulation of cell population proliferation; and positive regulation of germinal center formation. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma. Orthologous to human TNFSF13 (TNF superfamily member 13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfsf13 |
| Official Name | TNF superfamily member 13 [Source:RGD Symbol;Acc:1305871] |
| Ensembl ID | ENSRNOG00000014171 |
| Bio databases IDs | |
| Aliases | TNF superfamily member 13 |
| Synonyms | 2310026N09Rik, APRIL, CD256, ligand, Similar to pafaha/lis1, TALL-2, TNF superfamily member 13, TNLG7B, TRDL-1, tumor necrosis factor (ligand) superfamily, member 13, tumour necrosis factor (ligand) superfamily, member 13, TWE-PRIL, UNQ383/PRO715, ZTNF2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnfsf13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- TNF homology domain
- TNF
- protein binding
- receptor binding
- cytokine
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Tnfsf13 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- April Mediated Signaling
- Communication between Innate and Adaptive Immune Cells
- Erythropoietin Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- RAR Activation
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- atopic dermatitis
- epithelial cancer
- systemic lupus erythematosus
- psoriasis
- primary antiphospholipid antibody syndrome
- arthritis
- non-small cell lung cancer
- IgA nephropathy
role in cell
- apoptosis
- quantity
- proliferation
- survival
- phosphorylation in
- expression in
- cell death
- differentiation
- migration
- antigen presentation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- intracellular space
- membrane surface
- cellular membrane
- endosomes
- Golgi Apparatus
- granules
- cytosol
- plasma membrane extracellular face
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnfsf13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of isotype switching to IgA isotypes
- immune response
- signal transduction
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- tumor necrosis factor receptor binding
- receptor agonist activity
- cytokine activity
- receptor binding