Abcc1 Gene Summary [Rat]
Enables ATPase-coupled transmembrane transporter activity; efflux transmembrane transporter activity; and organic anion transmembrane transporter activity. Involved in several processes, including long-chain fatty acid import across plasma membrane; phospholipid efflux; and xenobiotic detoxification by transmembrane export across the plasma membrane. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 77 and chronic obstructive pulmonary disease. Orthologous to human ABCC1 (ATP binding cassette subfamily C member 1 (ABCC1 blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcc1 |
| Official Name | ATP binding cassette subfamily C member 1 [Source:RGD Symbol;Acc:3112] |
| Ensembl ID | ENSRNOG00000022305 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily C member 1 |
| Synonyms | ABC29, ABCC, Abcc1a, Abcc1b, ATP binding cassette subfamily C member 1, ATP-binding cassette, sub-family C member 1, ATP binding cassette subfamily C member 1 (ABCC1 blood group), Avcc1a, DFNA77, GS-X, LOC100362747, LOC100365034, LOC103693258, Mdrap, MRP, MRP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abcc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic acid transporter
- efflux permease
- phosphonate ABC transporter, ATP-binding protein
- conjugate transporter
- nitrate transport ATP-binding subunits C and D
- heme ABC exporter, ATP-binding protein CcmA
- nucleotide-binding domain
- thiol reductant ABC exporter, CydC subunit
- energy-coupling factor transporter ATPase
- xenobiotic-transporting ATPase
- multi drug resistance-associated protein (MRP)
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- ATPase activity, coupled to transmembrane movement of substances
- lipid A export permease/ATP-binding protein MsbA
- amide transporter
- walker type A motif
- organic anion transporter
- inorganic anion transporter
- tripeptide transporter
- ABC transporter transmembrane region
- lipid transporter
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- long-chain fatty acid transporter
- vitamin B12-transporting ATPase
- thiol reductant ABC exporter, CydD subunit
- cystic fibrosis transmembrane conductor regulator (CFTR)
- xenobiotic transporter
- cytoplasmic loop
- transmembrane domain
- sphingolipid transporter
- ABC transporter
- transporter
Pathways
Biological processes and signaling networks where the Abcc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- familial breast cancer
- organismal death
- sepsis
- gout
- cholestasis
- adenoid cystic carcinoma
role in cell
- activation in
- apoptosis
- expression in
- quantity
- migration
- accumulation in
- depolarization
- differentiation
- sensitivity
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane vesicles
- membrane fraction
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- apical membrane
- basolateral membrane
- basal membrane
- lateral plasma membrane
- mitochondrial outer membrane
- detergent insoluble microdomains
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abcc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cyclic nucleotide transport
- leukotriene transport
- transmembrane transport
- leukotriene metabolic process
- positive regulation of inflammatory response
- heme catabolic process
- response to xenobiotic stimulus
- cell chemotaxis
- phospholipid translocation
- xenobiotic metabolic process
- transepithelial transport
- cellular response to oxidative stress
- glutathione transmembrane transport
- xenobiotic transport
- cobalamin transport
- sphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- basal plasma membrane
- extracellular vesicular exosome
- membrane
- basolateral plasma membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- xenobiotic transporter activity
- ATPase activity, coupled to transmembrane movement of substances
- lipid-transporting ATPase activity
- cobalamin-transporting ATPase activity
- glutathione S-conjugate-exporting ATPase activity
- efflux transmembrane transporter activity
- xenobiotic-transporting ATPase activity
- anion transmembrane-transporting ATPase activity
- sphingolipid transporter activity
- carboxylic acid transmembrane transporter activity
- ATP binding
- glutathione transmembrane transporter activity