Ddias Gene Summary [Rat]
Predicted to be involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage and regulation of DNA stability. Predicted to act upstream of or within several processes, including cellular response to hydroperoxide; cellular response to radiation; and negative regulation of fibroblast apoptotic process. Predicted to be active in cytoplasm and nucleus. Orthologous to human DDIAS (DNA damage induced apoptosis suppressor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddias |
| Official Name | DNA damage-induced apoptosis suppressor [Source:RGD Symbol;Acc:1559690] |
| Ensembl ID | ENSRNOG00000022521 |
| Bio databases IDs | |
| Aliases | DNA damage-induced apoptosis suppressor |
| Synonyms | 4632434I11Rik, C11orf82, DNA damage-induced apoptosis suppressor, FLJ25416, Noxin, RGD1559690 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ddias often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- colorectal cancer
- osteoporosis
regulates
role in cell
- apoptosis
- number
- quantity
- development
- G1 phase
- cell cycle progression
- sensitivity
- response by
- hematopoiesis
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ddias gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm