Cenpj Gene Summary [Rat]
Predicted to enable several functions, including gamma-tubulin binding activity; identical protein binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including cilium assembly; microtubule cytoskeleton organization; and positive regulation of cell cycle process. Predicted to act upstream of or within several processes, including astral microtubule nucleation; organelle assembly; and positive regulation of non-motile cilium assembly. Predicted to be located in ciliary basal body and cytoplasm. Predicted to be part of procentriole replication complex. Predicted to be active in centriole and centrosome. Human ortholog(s) of this gene implicated in Seckel syndrome 4; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 6. Orthologous to human CPAP (centrosome assembly and centriole elongation protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cenpj |
| Official Name | centromere protein J [Source:RGD Symbol;Acc:1310464] |
| Ensembl ID | ENSRNOG00000022597 |
| Bio databases IDs | |
| Aliases | centromere protein J |
| Synonyms | 4932437H03, 4932437H03Rik, BM032, CENP-J, centrosome assembly and centriole elongation protein, Gm81, LAP, LIP1, LIP7, MCPH6, Sas-4, SASS4, SCKL4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cenpj often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- gamma-tubulin binding
- transcription regulator
- transcription co-activator
- protein kinase binding
- tubulin binding
- protein domain specific binding
- protein binding
- T-complex protein 10 C-terminus
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- autosomal recessive primary microcephaly type 6
- growth failure
- hereditary disorder
- Seckel syndrome 4
- autosomal recessive primary microcephaly type 1
- microcephaly type 6 with or without short stature
- autosomal recessive primary microcephaly
- Seckel syndrome 5
role in cell
- expression in
- proliferation
- apoptosis
- formation
- formation in
- assembly
- loss in
- misalignment
- elongation
- duplication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- basal bodies
- centrosome
- centriole
- microtubules
- cytosol
- spindle pole
- pro-centriole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cenpj gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of G1/S transition of mitotic cell cycle
- cilium morphogenesis
- centriole replication
- microtubule nucleation
- smoothened signaling pathway
- positive regulation of centriole replication
- microtubule polymerization
- regulation of centriole replication
- motile cilium assembly
- regulation of mitotic spindle organization
- positive regulation of JAK-STAT cascade
- cell division
- astral microtubule nucleation
- positive regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- centrosome
- cilium basal body
- centriole
- gamma-tubulin small complex
- cytoplasm
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein kinase binding
- protein domain specific binding
- identical protein binding
- protein binding
- transcription coactivator activity
- gamma-tubulin binding