Sema3a Gene Summary [Rat]
Predicted to enable chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Involved in negative regulation of axon extension. Acts upstream of or within axon guidance. Located in axon and dendrite. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia. Orthologous to human SEMA3A (semaphorin 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sema3a |
| Official Name | semaphorin 3A [Source:RGD Symbol;Acc:3657] |
| Ensembl ID | ENSRNOG00000023337 |
| Bio databases IDs | |
| Aliases | semaphorin 3A |
| Synonyms | COLL1, HH16, Hsema-I, Hsema-III, LOC100503462, SEMA1, SEMAD, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, SEMAIII, SEMAL, SEMAPHORIN 3A, SemD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sema3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- semaphorin receptor binding
- chemorepellant
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- receptor binding
- basic domain
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema3a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- carpal tunnel syndrome
- acute myeloid leukemia
- prostate cancer
- COVID-19
- Alzheimer disease
- sinus bradycardia
- glioblastoma multiforme of brain
- brain glioma cancer
- glioblastoma cancer
role in cell
- expression in
- function
- differentiation
- proliferation
- formation
- cell death
- apoptosis
- dephosphorylation in
- phosphorylation in
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- insoluble fractions
- glutaminergic synapse
- cell surface
- cell periphery
- membrane surface
- granules
- dendritic spines
- synapse
- perikaryon
- axons
- dendrites
- axon terminals
- excitatory synapses
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sema3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- axonogenesis involved in innervation
- negative chemotaxis
- motor axon guidance
- trigeminal nerve structural organization
- axon guidance
- facial nerve structural organization
- olfactory bulb development
- axon extension involved in axon guidance
- branchiomotor neuron axon guidance
- nerve development
- sympathetic nervous system development
- sensory system development
- neuron migration
- regulation of axon extension involved in axon guidance
- neural crest cell migration
- negative regulation of axon extension
- negative regulation of neuron projection development
- positive regulation of JNK cascade
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- extracellular region
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- semaphorin receptor binding