Sema3a Gene Summary [Mouse]
Enables chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Involved in several processes, including nervous system development; positive regulation of male gonad development; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including dichotomous subdivision of terminal units involved in salivary gland branching; negative regulation of axon extension involved in axon guidance; and neuron projection development. Located in extracellular space. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia. Orthologous to human SEMA3A (semaphorin 3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Sema3a |
| Official Name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A [Source:MGI Symbol;Acc:MGI:107558] |
| Ensembl ID | ENSMUSG00000028883 |
| Bio databases IDs | |
| Aliases | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
| Synonyms | COLL1, HH16, Hsema-I, Hsema-III, LOC100503462, SEMA1, SEMAD, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, SEMAIII, SEMAL, SEMAPHORIN 3A, SemD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sema3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- semaphorin receptor binding
- chemorepellant
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- receptor binding
- basic domain
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the Sema3a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- carpal tunnel syndrome
- acute myeloid leukemia
- prostate cancer
- COVID-19
- Alzheimer disease
- sinus bradycardia
- glioblastoma multiforme of brain
- brain glioma cancer
- glioblastoma cancer
role in cell
- expression in
- function
- differentiation
- proliferation
- formation
- cell death
- apoptosis
- dephosphorylation in
- phosphorylation in
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- insoluble fractions
- glutaminergic synapse
- cell surface
- cell periphery
- membrane surface
- granules
- dendritic spines
- synapse
- perikaryon
- axons
- dendrites
- axon terminals
- excitatory synapses
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sema3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- axonogenesis involved in innervation
- negative chemotaxis
- motor axon guidance
- trigeminal nerve structural organization
- axon guidance
- facial nerve structural organization
- olfactory bulb development
- axon extension involved in axon guidance
- branchiomotor neuron axon guidance
- nerve development
- sympathetic nervous system development
- sensory system development
- neuron migration
- regulation of axon extension involved in axon guidance
- neural crest cell migration
- negative regulation of axon extension
- negative regulation of neuron projection development
- positive regulation of JNK cascade
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- extracellular region
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- chemorepellent activity
- semaphorin receptor binding