Npr1 Gene Summary [Rat]
Enables guanylate cyclase activity. Involved in several processes, including cGMP-mediated signaling; positive regulation of cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npr1 |
| Official Name | natriuretic peptide receptor 1 [Source:RGD Symbol;Acc:3195] |
| Ensembl ID | ENSRNOG00000014684 |
| Bio databases IDs | |
| Aliases | natriuretic peptide receptor 1 |
| Synonyms | ANPa, ANPRA, GC-A, Gc alpha, Gc α, Guanylate cyclase, GUC2A, GUCY2A, natriuretic peptide receptor 1, NPR-A, Particulate GC-A, pGC-A, Pndr |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Npr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- natriuretic peptide receptor
- Receptor family ligand binding region
- hormone binding
- Protein kinase (unclassified specificity)
- guanylate cyclase domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- kinase-like domain
- enzyme
- protein binding
- Protein kinase domain
- polypeptide hormone binding
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- cytoplasmic domain
- transmembrane/cytoplasmic domain
- Type 1 periplasmic binding fold superfamily
- guanylate cyclase
- intracellular domain
- Class III nucleotidyl cyclases
- Adenylyl- / guanylyl cyclase, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Npr1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Antiproliferative Role of Somatostatin Receptor 2
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Endothelin-1 Signaling
- Gap Junction Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Phototransduction Pathway
- Relaxin Signaling
- Sperm Motility
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- coronary artery disease
- hypertension
- cardiomyopathy
- heart failure
- fibrosis
- heart disease
- perivascular fibrosis
- congestive heart failure
- cardiac hypertrophy
role in cell
- expression in
- quantity
- phosphorylation in
- apoptosis
- proliferation
- chemotaxis
- size
- dissociation
- cross-sectional area
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- cell surface
- cellular membrane
- podocyte slit diaphragm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Npr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- cGMP biosynthetic process
- cGMP-mediated signaling
- dopamine metabolic process
- G-protein coupled receptor signaling pathway
- receptor guanylyl cyclase signaling pathway
- regulation of vascular permeability
- cell surface receptor signaling pathway
- regulation of blood pressure
- body fluid secretion
- positive regulation of renal sodium excretion
- negative regulation of cell growth
- negative regulation of smooth muscle cell proliferation
- positive regulation of cGMP-mediated signaling
- positive regulation of urine volume
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- peptide receptor activity
- ATP binding
- G-protein coupled peptide receptor activity
- hormone binding
- guanylate cyclase activity
- protein kinase activity
- peptide hormone binding
- adenylate cyclase activity
- natriuretic peptide receptor activity