Tcl1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Involved in activation of protein kinase B activity. Acts upstream of or within negative regulation of gene expression; regulation of stem cell population maintenance; and somatic stem cell population maintenance. Located in cell cortex; ooplasm; and pronucleus. Is expressed in several structures, including early conceptus; hemolymphoid system gland; liver; and seminiferous cord. Orthologous to human TCL1A (TCL1 family AKT coactivator A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcl1 |
| Official Name | T cell lymphoma breakpoint 1 [Source:MGI Symbol;Acc:MGI:1097166] |
| Ensembl ID | ENSMUSG00000041359 |
| Bio databases IDs | |
| Aliases | T cell lymphoma breakpoint 1 |
| Synonyms | LOC683950, T cell leukaemia/lymphoma 1A, T cell leukemia/lymphoma 1A, T cell lymphoma breakpoint 1, TCL1, TCL1 family AKT coactivator A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- transcription regulator
- protein kinase binding
- TCL1/MTCP1 family
- Akt-binding domain
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Tcl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic lymphocytic leukemia
- hepatomegaly
- cancer
- splenomegaly
- B-cell non-Hodgkin disease
- non-Hodgkin disease
- B cell cancer
- mature B-cell neoplasia
- lymphomagenesis
role in cell
- expression in
- proliferation
- activation
- apoptosis
- transmembrane potential
- activation in
- number
- growth
- cellular infiltration by
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell cortex
- Endoplasmic Reticulum
- cytosol
- microsome
- nucleoplasm
- pronucleus
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- protein serine/threonine kinase activator activity
- protein binding