Jph4 Gene Summary [Rat]
Predicted to enable clathrin adaptor activity. Predicted to be involved in Golgi to vacuole transport. Predicted to be located in Golgi-associated vesicle; membrane; and transport vesicle. Predicted to be part of AP-1 adaptor complex. Predicted to be active in synapse. Orthologous to human AP1G2 (adaptor related protein complex 1 subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Jph4 |
| Official Name | junctophilin 4 [Source:RGD Symbol;Acc:1303170] |
| Ensembl ID | ENSRNOG00000025589 |
| Bio databases IDs | |
| Aliases | junctophilin 4 |
| Synonyms | 9330157P13RIK, AI425998, JP-4, JPHL1, junctophilin 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Jph4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane Occupation and Recognition Nexus motif
- MORN repeat
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometrial cancer
- infertility condition
- Huntington disease
- colon epithelial cancer
- colon carcinoma
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- activation in
- long-term potentiation
- activation
- plasticity
- transport in
- store-operated calcium influx in
- excitatory postsynaptic potential
- afterhyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum-plasma membrane junction
- cellular membrane
- sarcoplasmic reticulum
- smooth endoplasmatic reticulum
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Jph4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic plasticity
- regulation of cytokine production
- learning
- regulation of store-operated calcium entry
- neuromuscular process controlling balance
- regulation of ryanodine-sensitive calcium-release channel activity
- calcium ion transport into cytosol
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- dendritic shaft
- smooth endoplasmic reticulum
- junctional sarcoplasmic reticulum membrane
- plasma membrane
- junctional membrane complex
Molecular Function
What the gene product does at the molecular level
- protein binding