Yod1 Gene Summary [Rat]
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Details
| Type | Protein Coding |
| Official Symbol | Yod1 |
| Official Name | YOD1 deubiquitinase [Source:RGD Symbol;Acc:1359726] |
| Ensembl ID | ENSRNOG00000025704 |
| Bio databases IDs | |
| Aliases | YOD1 deubiquitinase |
| Synonyms | 6330564D18Rik, 9930028C20Rik, DKFZp451J1719, DUBA8, Hshin7, OTUD2, PRO0907, YOD1 deubiquitinase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Yod1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Ubl1_cv_Nsp3_N-like
- ubiquitin-specific protease
- enzyme
- protein binding
- zinc finger domain
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- organismal death
- hepatomegaly
role in cell
- expression in
- production in
- activation in
- phosphorylation in
- proliferation
- growth
- paclitaxel resistance
- S phase
- migration
- cisplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Yod1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- protein K11-linked deubiquitination
- endoplasmic reticulum unfolded protein response
- protein K29-linked deubiquitination
- macroautophagy
- protein K63-linked deubiquitination
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- ubiquitin protein ligase binding
- metal ion binding