Yod1 Gene Summary [Mouse]
Predicted to enable K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including ERAD pathway; negative regulation of retrograde protein transport, ER to cytosol; and protein deubiquitination. Predicted to be located in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and respiratory system. Orthologous to human YOD1 (YOD1 deubiquitinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Yod1 |
| Official Name | YOD1 deubiquitinase [Source:MGI Symbol;Acc:MGI:2442596] |
| Ensembl ID | ENSMUSG00000046404 |
| Bio databases IDs | |
| Aliases | YOD1 deubiquitinase |
| Synonyms | 6330564D18Rik, 9930028C20Rik, DKFZp451J1719, DUBA8, Hshin7, OTUD2, PRO0907, YOD1 deubiquitinase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Yod1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Ubl1_cv_Nsp3_N-like
- ubiquitin-specific protease
- enzyme
- protein binding
- zinc finger domain
- OTU-like cysteine protease
- OTU (ovarian tumor) domain family
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- organismal death
- hepatomegaly
role in cell
- expression in
- production in
- activation in
- phosphorylation in
- proliferation
- growth
- paclitaxel resistance
- S phase
- migration
- cisplatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Yod1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- protein K11-linked deubiquitination
- endoplasmic reticulum unfolded protein response
- protein K29-linked deubiquitination
- macroautophagy
- protein K63-linked deubiquitination
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- ubiquitin protein ligase binding
- metal ion binding