Syt7 Gene Summary [Rat]
Enables several functions, including calcium ion binding activity; calcium-dependent phospholipid binding activity; and syntaxin binding activity. Involved in several processes, including calcium ion regulated lysosome exocytosis; plasma membrane repair; and regulation of vesicle-mediated transport. Located in dense core granule and lysosome. Is active in hippocampal mossy fiber to CA3 synapse and presynaptic membrane. Orthologous to human SYT7 (synaptotagmin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syt7 |
| Official Name | synaptotagmin 7 [Source:RGD Symbol;Acc:62013] |
| Ensembl ID | ENSRNOG00000026432 |
| Bio databases IDs | |
| Aliases | synaptotagmin 7 |
| Synonyms | B230112P13RIK, IPCA-7, PCANAP7, SYNAPTOTAGMIN 7, synaptotagmin VII, SYT-VII |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Syt7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- phospholipid binding
- palmitoylation site
- calmodulin binding
- calcium ion binding
- calcium-dependent phospholipid binding
- clathrin binding
- protein binding
- syntaxin binding
- binding protein
- cytoplasmic domain
- phosphatidylinositol-4,5-bisphosphate binding
- Protein kinase C conserved region 2 (CalB)
- transporter
- C2 domain
Pathways
Biological processes and signaling networks where the Syt7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- autoimmune disease
- lung adenocarcinoma
- fibrosis
- lung adenocarcinoma formation
- tubulo-interstitial fibrosis
- androgenic alopecia
- myositis
role in cell
- phagocytosis by
- invasion
- membrane fusion
- outgrowth
- repair
- upregulation in
- outgrowth in
- function
- resealing
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic plasma membrane fractions
- glutaminergic synapse
- cellular membrane
- Plasma Membrane
- vesicles
- lysosome
- presynaptic membrane
- synaptic vesicles
- synapse
- peroxisomes
- secretory granules
- perikaryon
- dendrites
- axon terminals
- presynaptic terminals
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Syt7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synaptic vesicle endocytosis
- phagosome-lysosome fusion
- regulation of glucagon secretion
- positive regulation of calcium ion-dependent exocytosis
- regulation of insulin secretion
- calcium ion-dependent exocytosis of neurotransmitter
- regulation of bone remodeling
- vesicle fusion
- plasma membrane repair
- phagocytosis
- regulation of phagocytosis
- vesicle-mediated cholesterol transport
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- synaptic vesicle
- synapse
- lysosomal membrane
- plasma membrane
- lysosome
- peroxisomal membrane
- peroxisome
- early phagosome
- extracellular vesicular exosome
- cytosol
- phagocytic vesicle membrane
- dense core granule
- synaptic vesicle membrane
- axon
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- calmodulin binding
- phosphatidylserine binding
- protein binding
- syntaxin binding
- calcium ion binding
- clathrin binding
- SNARE binding
- calcium-dependent phospholipid binding